Migrating synovial fibroblasts: a homogenous population?
نویسندگان
چکیده
منابع مشابه
Synovial fibroblasts in 2017
Stromal cells like synovial fibroblasts gained great interest over the years, since it has become clear that they strongly influence their environment and neighbouring cells. The current review describes the role of synovial fibroblasts as cells of the innate immune system and expands on their involvement in inflammation and cartilage destruction in rheumatoid arthritis (RA). Furthermore, epige...
متن کاملSynovial intimal fibroblasts.
Cells of the normal synovial intima fall into two clearly separable types, macrophages and fibroblasts.' 2 In diseased tissue separation on traditional criteria such as ultrastructure may be less clear cut, but recent studies using techniques for identifying specific gene products related to cell lineage suggest that this distinction remains valid.3 ' The fibroblasts of synovial intima have bee...
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Mesenchymal cell migration as exhibited by fibroblasts is distinct from amoeboid cell migration and is characterized by dynamic competition among multiple protrusions, which determines directional persistence and responses to spatial cues. Localization of phosphoinositide 3-kinase (PI3K) signaling is thought to play a broadly important role in cell motility, yet the context-dependent functions ...
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OBJECTIVES Rheumatoid arthritis (RA) is a chronic disease characterised by irreversible destruction of the affected joints. As aggressive transformed-appearing synovial fibroblasts are commonly found at the site of invasion of the rheumatoid synovium into the adjacent cartilage and bone, the presence of microsatellite instability (MSI) and expression of mismatch repair enzymes as a possible mec...
متن کاملProliferation of synovial lining cells and fibroblasts.
After in vitro incubation with 3H-thymidine, the proliferation of synovial lining cells and fibroblasts was investigated in surgically-removed articular tissue. Under normal conditions, in nonrheumatoid arthritis and in osteoarthrosis, low proliferation rates for both cell types were observed. In rheumatoid arthritis, the rate of proliferation of both cell types was usually increased. An increa...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 2010
ISSN: 0003-4967
DOI: 10.1136/ard.2010.129643n